Drug combination: Asentra 50 & Lokren & Triplixam & Sortis & Trombex & Geratam

Compared drugs
Asentra 50 (sertraline)
Lokren (betaxolol)
Triplixam (perindopril, amlodipine and indapamide)
Sortis (atorvastatin)
Trombex (clopidogrel)
Geratam (piracetam)

Drug Interaction

Asentra 50 & Lokren
The metabolism of Betaxolol can be decreased when combined with Sertraline.

Asentra 50 & Triplixam
Sertraline may increase the hyponatremic activities of Indapamide.

Asentra 50 & Sortis
The risk or severity of adverse effects can be increased when Sertraline is combined with Atorvastatin.

Asentra 50 & Trombex
The serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Sertraline resulting in a loss in efficacy.

Lokren & Triplixam
The risk or severity of adverse effects can be increased when Betaxolol is combined with Amlodipine.

Triplixam & Sortis
The risk or severity of adverse effects can be increased when Amlodipine is combined with Atorvastatin.

Triplixam & Trombex
The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Amlodipine.

Food interactions and other recommendations

Asentra 50: Avoid alcohol. Avoid St.John's Wort. Avoid taking with grapefruit juice. Take with food.
Triplixam: Avoid natural licorice. Grapefruit down regulates post-translational expression of CYP3A4, the major metabolizing enzyme of amlodipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of amlodipine and may cause toxicity. Avoid grapefruit products while on this medication. Take without regard to meals.
Sortis: Avoid alcohol. Avoid drastic changes in dietary habit. Avoid taking grapefruit or grapefruit juice throughout treatment. Grapefruit can significantly increase serum levels of this product. Food may decrease maximum plasma levels and area under the curve, but this is clinically inconsequential according to the manufacturer. Take with low fat meal.

Combination of side effects

Combination of common side effects of all medicines

For some of the comparators, there is not enough information available, contact us by email and we will list the side effects additionally
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